{"id":7298,"date":"2022-12-06T15:44:59","date_gmt":"2022-12-06T15:44:59","guid":{"rendered":"https:\/\/edwardseducation.com\/edwardsmasters\/?p=7298"},"modified":"2023-04-23T11:01:26","modified_gmt":"2023-04-23T11:01:26","slug":"multicentre-large-scale-propensity-weighted-comparison-of-three-aortic-bioprostheses-conventional-stented-new-generation-stented-and-rapid-deployment","status":"publish","type":"post","link":"https:\/\/dev.edwardseducation.com\/edwardsmasters\/multicentre-large-scale-propensity-weighted-comparison-of-three-aortic-bioprostheses-conventional-stented-new-generation-stented-and-rapid-deployment\/","title":{"rendered":"Multicentre, large scale, propensity-weighted comparison of three aortic bioprostheses: conventional stented, new-generation stented and rapid deployment"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7298\" class=\"elementor elementor-7298\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-63034de elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"63034de\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b117ae5\" data-id=\"b117ae5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5cca94 elementor-widget elementor-widget-text-editor\" data-id=\"b5cca94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>D\u2019Onofrio A, Cibin G, Lorenzoni G, Tessari C, Luzi G, Manzan E, Gerosa G and the INTU-ITA and RES-ITA Investigators.<\/p><p><em>Presented at 36<sup>th<\/sup> European Association for Cardio-Thoracic Surgery Annual Meeting, 2022.\u00a0 \u00a0<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-14b448c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"14b448c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-004bdd5\" data-id=\"004bdd5\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d54873 elementor-widget elementor-widget-heading\" data-id=\"8d54873\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Key points:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c21ce4f elementor-widget elementor-widget-text-editor\" data-id=\"c21ce4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>All three valves demonstrated excellent haemodynamic outcomes with no differences in major postoperative complications.<\/li>\n<li>Operative times were lowest with the EDWARDS INTUITY valve; new pacemaker implantation was least common in patients receiving an INSPIRIS RESILIA valve.<\/li>\n<li>The EDWARDS INTUITY valve and the INSPIRIS RESILIA valve resulted in similar postoperative aortic gradients that were significantly lower than in patients with a Carpentier-Edwards PERIMOUNT Magna Ease valve.<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c6d0ee4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c6d0ee4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fba092c\" data-id=\"fba092c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3fa57a0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3fa57a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e37ef44\" data-id=\"e37ef44\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1ba7b63 elementor-widget elementor-widget-heading\" data-id=\"1ba7b63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Background information<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b09caf5 elementor-widget elementor-widget-text-editor\" data-id=\"b09caf5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Several different aortic valve bioprostheses with different design characteristics and haemodynamic properties are available<\/li><li>Options include conventional stented (CS), new-generation stented (NGS) and rapid deployment (RD) valves.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f2d92dc elementor-widget elementor-widget-heading\" data-id=\"f2d92dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aims<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb11537 elementor-widget elementor-widget-text-editor\" data-id=\"cb11537\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>To evaluate early clinical and haemodynamic outcomes of CS, NGS and RD aortic valve bioprostheses.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31df1c1 elementor-widget elementor-widget-heading\" data-id=\"31df1c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Type of study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90fa600 elementor-widget elementor-widget-text-editor\" data-id=\"90fa600\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Multicentre, retrospective, observational study, with a propensity score weighting approach, that merged data from the INTU-ITA and the RES-ITA registry.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60f2cf9 elementor-widget elementor-widget-heading\" data-id=\"60f2cf9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Endpoints<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7639f97 elementor-widget elementor-widget-text-editor\" data-id=\"7639f97\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Outcomes included operative times, postoperative complication rates and haemodynamic function.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-937e6e2 elementor-widget elementor-widget-heading\" data-id=\"937e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Methods<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-86b7569 elementor-widget elementor-widget-text-editor\" data-id=\"86b7569\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The study enrolled patients from 27 cardiac surgery centres who underwent surgical aortic valve replacement for aortic valve stenosis between January 2017 and December 2020 and received either a PERIMOUNT Magna Ease valve (CS), an INSPIRIS RESILIA valve (NGS)\u00a0or an EDWARDS INTUITY (RD) valve.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-06fae8a\" data-id=\"06fae8a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9617afb elementor-widget elementor-widget-heading\" data-id=\"9617afb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Results<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-abbe715 elementor-widget elementor-widget-text-editor\" data-id=\"abbe715\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Study Population<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eee41bb elementor-widget elementor-widget-text-editor\" data-id=\"eee41bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The study included 2,589 patients.<\/li><li>Across the three groups, mean age was 72 (64\u201378) years, 40% patients were female and average body surface area was 1.83 (1.69\u20131.96) m2. Mean STS score was 1.66 (1.08\u20132.58) and 89% patients were in NYHA class &gt;II.<\/li><\/ul><ul><li>For the three-arm comparison, the EDWARDS INTUITY arm was chosen as the reference, with comparisons adjusted for factors including age, gender, comorbidities, STS score, NYHA and cardiac history.<\/li><\/ul><ul><li>Most patients (65%, n=1,688) received an EDWARDS INTUITY valve; 605 (23%, n=605) received an INSPIRIS RESILIA valve and 296 (12%, n=296) a PERIMOUNT Magna Ease valve.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-499959d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"499959d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-76c77b1\" data-id=\"76c77b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8f8e7f6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8f8e7f6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f2ce6a1\" data-id=\"f2ce6a1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b90d4d3 elementor-widget elementor-widget-text-editor\" data-id=\"b90d4d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>INSPIRIS RESILIA was implanted in younger patients (Mean age: INSPIRIS RESILIA 60 [53\u201365] years; PERIMOUNT Magna Ease 72 [66\u201376] years; EDWARDS INTUITY 75 [66\u201376] years) with lower risk scores (STS score (%): INSPIRIS RESILIA 0.95 [0.65\u20131.52]; PERIMOUNT Magna Ease 1.3 [0.95\u20132.08]; EDWARDS INTUITY 1.9 [1.32\u20132.82])<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3af006 elementor-widget elementor-widget-text-editor\" data-id=\"d3af006\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Operative times<\/strong><\/p><ul><li>The EDWARDS INTUITY valve allowed for shorter procedural times than the other bioprostheses (Table 1).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b5d5b5 elementor-widget elementor-widget-text-editor\" data-id=\"3b5d5b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Table 1. Median operative times<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a9f139 elementor-widget elementor-widget-image\" data-id=\"2a9f139\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"550\" height=\"248\" src=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P13.jpg\" class=\"attachment-2048x2048 size-2048x2048 wp-image-7448\" alt=\"\" srcset=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P13.jpg 550w, https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P13-300x135.jpg 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f60970 elementor-widget elementor-widget-text-editor\" data-id=\"3f60970\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Postoperative complications<\/b><\/p><ul><li>All three study groups had a device success rate of 96%.<\/li><li>The incidence of major postoperative complications was similar across all study groups.<\/li><li>New pacemaker implantations were significantly less frequent in the INSPIRIS RESILIA valve group (rate of 2%) than in the other study arms (6% in both the EDWARDS INTUITY valve and PERIMOUNT Magna Ease valve group).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97008b6 elementor-widget elementor-widget-text-editor\" data-id=\"97008b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Haemodynamic function<\/b><\/p><ul><li>Haemodynamic outcomes were better with the EDWARDS INTUITY valve compared with the PERIMOUNT Magna Ease valve, whereas there was no difference between the INSPIRIS RESILIA valve and EDWARDS INTUITY (Figure 1).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-16024cd\" data-id=\"16024cd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92976da elementor-widget elementor-widget-text-editor\" data-id=\"92976da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Figure 1. Postoperative mean aortic gradient.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad3cbb3 elementor-widget elementor-widget-image\" data-id=\"ad3cbb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"577\" height=\"365\" src=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P14.jpg\" class=\"attachment-large size-large wp-image-7449\" alt=\"\" srcset=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P14.jpg 577w, https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P14-300x190.jpg 300w\" sizes=\"(max-width: 577px) 100vw, 577px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20f434d elementor-widget elementor-widget-heading\" data-id=\"20f434d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b984fc9 elementor-widget elementor-widget-text-editor\" data-id=\"b984fc9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>All three bioprostheses gave excellent haemodynamic and clinical outcomes, with significantly lower gradients with EDWARDS INTUITY valve <em>vs <\/em>PERIMOUNT Magna Ease valve. There was no difference in gradients between EDWARDS INTUITY and INSPIRIS RESILIA valves. Operative times were shortest with the EDWARDS INTUITY valve and the incidence of pacemaker implantation lowest among patients with INSPIRIS RESILIA valve. The rate of major postoperative complications was similar across all three study groups.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-975e666 elementor-widget elementor-widget-text-editor\" data-id=\"975e666\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>This document is a summary of the D\u2019Onofrio A <\/em>et al. <em>presentation and covers key information including aim, type of study, methods, results, limitations and conclusions.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd6b5c4 elementor-widget elementor-widget-heading\" data-id=\"cd6b5c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The full publication is available at:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0540cf5 elementor-widget elementor-widget-text-editor\" data-id=\"0540cf5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000\"><strong><a style=\"color: #000000\" href=\"https:\/\/eacts2022.process.y-congress.com\/scientificProcess\/Schedule\/?setLng=en#filters=[{%22name%22:%22fulltext%22,%22values%22:[%22d'onofrio%22]}]\">https:\/\/bit.ly\/Donofrio2022<\/a><\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6090034 elementor-widget elementor-widget-heading\" data-id=\"6090034\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Abbreviations:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e049bcf elementor-widget elementor-widget-image\" data-id=\"e049bcf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"409\" height=\"143\" src=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P17.jpg\" class=\"attachment-large size-large wp-image-7450\" alt=\"\" srcset=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P17.jpg 409w, https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P17-300x105.jpg 300w\" sizes=\"(max-width: 409px) 100vw, 409px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e2a98eb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e2a98eb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7eb6cb2\" data-id=\"7eb6cb2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92b277b elementor-widget elementor-widget-text-editor\" data-id=\"92b277b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients.<\/p><p><strong>Important<\/strong> <strong>safety<\/strong><strong> information:<\/strong><\/p><p><strong>Use<\/strong> <strong>of<\/strong> <strong>the<\/strong> <strong>EDWARDS<\/strong> <strong>INTUITY<\/strong> <strong>Elite<\/strong> <strong>valve<\/strong> <strong>system<\/strong> <strong>may<\/strong> <strong>be<\/strong> <strong>associated<\/strong> <strong>with<\/strong> <strong>new<\/strong> <strong>or<\/strong> <strong>worsened<\/strong> <strong>conduction<\/strong> <strong>disturbances,<\/strong> <strong>which<\/strong><strong> may require a permanent cardiac pacemaker implant (PPI). The rate of PPI for the EDWARDS INTUITY Elite valve is within the range reported in the literature for various rapid deployment valves, but higher than that reported for surgical aortic valves. Physicians should assess the benefits and risks of the EDWARDS INTUITY Elite valve prior to implantation. See instructions for use for additional information.<\/strong><\/p><p><strong>Medical<\/strong> <strong>device<\/strong> <strong>for<\/strong> <strong>professional<\/strong> <strong>use.<\/strong> <strong>For<\/strong> <strong>a<\/strong> <strong>listing<\/strong> <strong>of<\/strong> <strong>indications,<\/strong> <strong>contraindications,<\/strong> <strong>precautions,<\/strong> <strong>warnings,<\/strong> <strong>and<\/strong> <strong>potential<\/strong><strong> adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).<\/strong><\/p><p>Edwards, Edwards Lifesciences, the stylized E logo, Carpentier-Edwards, Carpentier-Edwards PERIMOUNT, Carpentier-Edwards PERIMOUNT Magna Ease, EDWARDS INTUITY, EDWARDS INTUITY Elite, INSPIRIS, INSPIRIS RESILIA, Magna, Magna Ease, PERI,<\/p><p>PERIMOUNT, PERIMOUNT Magna and RESILIA are trademarks or service marks of Edwards Lifesciences Corporation. All other trademarks are the property of their respective owners.<\/p><p>\u00a9 2022 Edwards Lifesciences Corporation. All rights reserved. PP&#8211;EU-5309 v1.0<\/p><p><strong>Edwards<\/strong> <strong>Lifesciences<\/strong> <strong>\u2022<\/strong> Route de l\u2019Etraz 70, 1260 Nyon, Switzerland \u2022 edwards.com<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>D\u2019Onofrio A, Cibin G, Lorenzoni G, Tessari [&hellip;]<\/p>\n","protected":false},"author":1869,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"topic_interest":[],"secondary_topic":[],"article_tags":[1224,609,616,1193],"anatomy":[],"topics":[],"course":[],"class_list":["post-7298","post","type-post","status-publish","format-standard","hentry"],"acf":{"views":"140","latestnews":false,"mostpopular":false,"header__style":"default","header__alternative-title":"","footer-section__show":true,"footer-section__object":false,"PathOrder":"0","slider__background-image":false,"slider__background-image_mobile":false,"slider__background-image_tablet":false,"slider_title":"","slider__subtitle":"","time_period":"","time_period_events":"","MobileLandscapeImage":false,"MobilePortraitImage":false,"MobilePortraitMode_aspect_ratio_3.5":false,"Images_aspect_ratio_4.3":false},"yoast_head":"<!-- This site is optimized with the 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