{"id":7356,"date":"2022-12-08T11:08:18","date_gmt":"2022-12-08T11:08:18","guid":{"rendered":"https:\/\/edwardseducation.com\/edwardsmasters\/?p=7356"},"modified":"2023-04-23T10:54:25","modified_gmt":"2023-04-23T10:54:25","slug":"indure-registry-clinical-and-quality-of-life-outcomes-of-surgical-aortic-valve-replacement-in-421-patients-under-60-years-of-age","status":"publish","type":"post","link":"https:\/\/dev.edwardseducation.com\/edwardsmasters\/indure-registry-clinical-and-quality-of-life-outcomes-of-surgical-aortic-valve-replacement-in-421-patients-under-60-years-of-age\/","title":{"rendered":"INDURE registry: Clinical and quality of life outcomes of surgical aortic valve replacement in 421 patients under 60 years of age"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7356\" class=\"elementor elementor-7356\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-63034de elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"63034de\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b117ae5\" data-id=\"b117ae5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5cca94 elementor-widget elementor-widget-text-editor\" data-id=\"b5cca94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Meuris B, Senage T, Borger M, Siepe M, Stefano P, Laufer G, Langanay T and De Paulis R, on behalf of the INDURE investigators<\/p><p><em>Presented at 36<\/em><em><sup>th\u00a0<\/sup><\/em><em>European Association for Cardio-Thoracic Surgery Annual Meeting, 2022.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-14b448c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"14b448c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-004bdd5\" data-id=\"004bdd5\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d54873 elementor-widget elementor-widget-heading\" data-id=\"8d54873\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Key points:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c21ce4f elementor-widget elementor-widget-text-editor\" data-id=\"c21ce4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>One-year clinical outcomes of patients aged \u226460 years within the INDURE registry were excellent, with few cardiovascular events and satisfactory valve performance<\/li><li>Patients achieved a general population standard quality of life (QoL) within 3\u20136 months post surgery<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c6d0ee4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c6d0ee4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fba092c\" data-id=\"fba092c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3fa57a0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3fa57a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e37ef44\" data-id=\"e37ef44\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1ba7b63 elementor-widget elementor-widget-heading\" data-id=\"1ba7b63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Background information<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b09caf5 elementor-widget elementor-widget-text-editor\" data-id=\"b09caf5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The treatment of comparatively young patients with implantation of surgical aortic bioprosthetic valves has raised questions about valve durability and longetivity.<sup>1<\/sup><\/li><li>The INSPIRIS RESILIA Durability Registry (INDURE) was designed to assess the performance of the INSPIRIS RESILIA bioprosthetic valve in patients aged 60 years or younger.<sup>1<\/sup><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f2d92dc elementor-widget elementor-widget-heading\" data-id=\"f2d92dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aims<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb11537 elementor-widget elementor-widget-text-editor\" data-id=\"cb11537\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>To evaluate the clinical and QoL outcomes of the INSPIRIS RESILIA valve in patients aged \u226460 years 1 year after surgical aortic valve replacement (SAVR).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31df1c1 elementor-widget elementor-widget-heading\" data-id=\"31df1c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Type of study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90fa600 elementor-widget elementor-widget-text-editor\" data-id=\"90fa600\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>A prospective, open-label, multicentre registry study.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60f2cf9 elementor-widget elementor-widget-heading\" data-id=\"60f2cf9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Endpoints<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7639f97 elementor-widget elementor-widget-text-editor\" data-id=\"7639f97\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><p>Endpoints included time-related valve safety according to VARC-2 guidelines and haemodynamic performance at 1 year and changes in QoL from baseline to 1 year.<\/p><\/li><li>Follow-up included Clinical Events Committee adjudication and CoreLab echocardiography adjudication at 1, 3 and 5 years.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-06fae8a\" data-id=\"06fae8a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9617afb elementor-widget elementor-widget-heading\" data-id=\"9617afb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Methods<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5bf2411 elementor-widget elementor-widget-text-editor\" data-id=\"5bf2411\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The study included patients aged 18\u201360 years undergoing SAVR.<\/li><li>Patients were followed-up with echocardiography after 1 year.<\/li><li>QoL was assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Short Form 12 item (version 2) Health Survey (SF12v2).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a40ed49 elementor-widget elementor-widget-heading\" data-id=\"a40ed49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Results<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-abbe715 elementor-widget elementor-widget-text-editor\" data-id=\"abbe715\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Patients<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eee41bb elementor-widget elementor-widget-text-editor\" data-id=\"eee41bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The 1-year analysis included 421 patients from 21 centres across Europe and Canada, with a mean age of 53.5 \u00b1 6.9 years, of whom 23.5% were female. Mean body surface area was 2.00 \u00b1 0.23 m2. Mean EuroSCORE II was 1.5 \u00b1 1.6% and 27.2% of patients were in NYHA class III\/IV.<\/li><\/ul><ul><li>The mean follow-up was 7 \u00b1 2.3 months.<\/li><li>Despite being of similar age to males, female patients had reduced body surface area (p&lt;0.001), increased EuroSCORE II (p&lt;0.001), as well as increased incidence of NYHA class III or IV (p&lt;0.001) and chronic obstructive pulmonary disease (p=0.005).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-499959d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"499959d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-76c77b1\" data-id=\"76c77b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8f8e7f6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8f8e7f6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f2ce6a1\" data-id=\"f2ce6a1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-970ef2d elementor-widget elementor-widget-text-editor\" data-id=\"970ef2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Clinical outcomes<\/b><\/p><ul><li>Clinical outcomes were excellent (Table 1), with a hospital mortality that was better than predicted (0.7% <em>vs 1.5<\/em>%).<\/li><li>Haemodynamic performance was satisfactory and stable throughout follow-up (mean pressure gradient at discharge was 7 \u00b1 4.3 mmHg, and 12.6 \u00b1 5.3 mmHg at one year).<\/li><\/ul><ul><li>No cases of structural valve deterioration (SVD) were recorded.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59f3b0b elementor-widget elementor-widget-text-editor\" data-id=\"59f3b0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Table 1. Safety outcomes early and between 31 days and 1 year after surgery<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68331c3 elementor-widget elementor-widget-image\" data-id=\"68331c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"513\" height=\"556\" src=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P4.jpg\" class=\"attachment-large size-large wp-image-7418\" alt=\"\" srcset=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P4.jpg 513w, https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P4-277x300.jpg 277w\" sizes=\"(max-width: 513px) 100vw, 513px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7866786 elementor-widget elementor-widget-text-editor\" data-id=\"7866786\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>QoL<\/b><\/p>\n<ul>\n<li>Within 3\u20136 months, QoL was restored to good-to-excellent on the KCCQ scale (score between 75\u2013100) and approximately matching the QoL of the general US population according to the SF12v2 scoring system (approximate score of 50).<\/li>\n<\/ul>\n<ul>\n<li>Female patients had generally significantly lower scores than men.<b style=\"font-family: MerriweatherSans;font-size: 1.14rem\">&nbsp;<\/b><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e9885db\" data-id=\"e9885db\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3c697a5 elementor-widget elementor-widget-heading\" data-id=\"3c697a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aec1caf elementor-widget elementor-widget-text-editor\" data-id=\"aec1caf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>One-year clinical outcomes of patients aged \u226460 years within the INDURE registry were excellent, with stable performance, better-than-predicted hospital mortality, low incidence of cardiovascular events, only four incidences of valve thrombosis (which did not require intervention), and no SVD events. Patients returned to expected QoL within 3\u20136 months after surgery. Notably, female patients tended to have a higher NYHA functional class at the time of surgery and had consistently lower QoL scores than males. Longer follow-up is underway.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-679d6a4 elementor-widget elementor-widget-heading\" data-id=\"679d6a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">References<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6c574c elementor-widget elementor-widget-text-editor\" data-id=\"f6c574c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Meuris B, Borger MA, Bourguignon T <em>et<\/em> <em>al<\/em>. Durability of bioprosthetic aortic valves in patients under the age of 60 years \u2013 rationale and design of the international INDURE registry. <em>J Cardiothorac Surg<\/em>. 2020; 15: 119.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b26244f elementor-widget elementor-widget-text-editor\" data-id=\"b26244f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>This document is a summary of the Meuris B <\/em>et al<em>. presentation and covers key information including aim, type of study, methods, results and conclusions.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-406cb63 elementor-widget elementor-widget-heading\" data-id=\"406cb63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The full publication is available at:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-03d1096 elementor-widget elementor-widget-text-editor\" data-id=\"03d1096\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/eacts2022.process.y-congress.com\/scientificProcess\/Schedule\/?setLng=en#filters=%5B%7B%22name%22:%22fulltext%22,%22values%22:%5B%22meuris%22%5D%7D%5D\"><b>https:\/\/bit.ly\/Meuris2022<\/b><\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a06efec elementor-widget elementor-widget-heading\" data-id=\"a06efec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Abbreviations:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ecaf5f1 elementor-widget elementor-widget-image\" data-id=\"ecaf5f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"276\" height=\"104\" src=\"https:\/\/dev.edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/Tab1111234.jpg\" class=\"attachment-large size-large wp-image-7360\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e2a98eb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e2a98eb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7eb6cb2\" data-id=\"7eb6cb2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92b277b elementor-widget elementor-widget-text-editor\" data-id=\"92b277b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients.<\/p><p><strong>Medical<\/strong> <strong>device<\/strong> <strong>for<\/strong> <strong>professional<\/strong> <strong>use.<\/strong> <strong>For<\/strong> <strong>a<\/strong> <strong>listing<\/strong> <strong>of<\/strong> <strong>indications,<\/strong> <strong>contraindications,<\/strong> <strong>precautions,<\/strong> <strong>warnings,<\/strong> <strong>and<\/strong> <strong>potential<\/strong><strong> adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).<\/strong><\/p><p>Edwards, Edwards Lifesciences, the stylized E logo, INSPIRIS, INSPIRIS RESILIA, and RESILIA are trademarks or service marks of Edwards Lifesciences Corporation. All other trademarks are the property of their respective owners.<\/p><p>\u00a9 2022 Edwards Lifesciences Corporation. All rights reserved. PP&#8211;EU-5306 v1.0<\/p><p><strong>Edwards<\/strong> <strong>Lifesciences<\/strong> <strong>\u2022<\/strong> Route de l\u2019Etraz 70, 1260 Nyon, Switzerland \u2022 edwards.com<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Meuris B, Senage T, Borger M, Siepe [&hellip;]<\/p>\n","protected":false},"author":1869,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"topic_interest":[],"secondary_topic":[],"article_tags":[1224,616,664,714],"anatomy":[],"topics":[],"course":[],"class_list":["post-7356","post","type-post","status-publish","format-standard","hentry"],"acf":{"views":"138","latestnews":false,"mostpopular":false,"header__style":"default","header__alternative-title":"","footer-section__show":true,"footer-section__object":false,"PathOrder":"0","slider__background-image":false,"slider__background-image_mobile":false,"slider__background-image_tablet":false,"slider_title":"","slider__subtitle":"","time_period":"","time_period_events":"","MobileLandscapeImage":false,"MobilePortraitImage":false,"MobilePortraitMode_aspect_ratio_3.5":false,"Images_aspect_ratio_4.3":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - 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